408 



CASE MR ? 



LTRIST, MACDONALD, MOSS, AND SKOOG 



CASE MR 9 



LBS 

 147 



146 



145 



144 



143 



142 



GM 



16 



BODY WEIGHT 



NITROGEN BALANCE 



URINARY EXCRETION 



""^j^i/t^LT"^ 



FECAL EXCRETION 



TTTT|TTTTpTn|TTTTjnil | MII | llll | llll|llll | llll|llll|llli 



5 6 7 8 9 10 II 12 13 14 

 FIVE - DAY PERIODS 



I8H 



16 



PHOSPHORUS BALANCE 



URINARY EXCRETION 



:!llLjJV|rA^-wi[y^ 



Fig. 7. Charts showing metabolic balance studies in Case No. 8. This 

 patient lost weight and was in continuous negative calcium, phosphorus, and 

 nitrogen balance. Polysaccharide treatment (Osseofac, Squibb) did not re- 

 store equilibrium. Human growth hormone produced nitrogen retention but 

 did not correct negative calcium and phosphorus balances. 



polysaccharide treatment was less during the first 10 days than with 

 the growth hormone. Thereafter, more Sy^'' was lost per day during 

 the polysaccharide regime, suggesting a higher rate of resorption of 

 bone which had been labeled with the isotope. Thus, the Sr""' ex- 

 creted during the early days comes mainly from soft tissue and from 

 Sr^^ deposited on preexisting bone salt crystals by exchange rather 

 than by incorporation into newly forming crystals (accretion). At 



