RAREFYING DISEASE OF THE SKELETON 



409 



47 ^GIVEN TOGETHER I.V. 



1ST STUDY (POLYSACCHARIDE) 

 J I I I I I I I I I ' I -I 



2ND STUDY (HUMAN GROWTH HORMONE) 

 J I I I I I I I I I I \ I I L_J 



20 40 60 



MINUTES POST INJECTION 



80 



Fig. 8. Radioisotope osteogram of MacDonald (1960) showing the changes 

 in rate of uptake of Sr^-"' and Ca^' in Case No. 8. The upper curve (first study) 

 represents the reaction of the tibia during a period of treatment with intra- 

 muscular injections of polysaccharides; this suggests a high rate of deposition 

 of bone mineral. The lower curve (second study) represents the response to 

 treatment with growth hormone; this is the same as obtained in untreated 

 nonosteoporotic subjects bv MacDonald. 



later times, however, the daily loss probably is derived primarilv 

 from continual resorption of mineral crystals which contained Sr'*^ 

 laid down earlier by accretion. 



Bone biopsy and tetracycline uptake. Oxvtetracvcline was in- 

 fused intravenously, in doses of 1.0 gm per liter of 0.9 per cent salt 

 solutions, on the 1st, 16th, and 39th days. A biopsy was performed 

 on the 42nd day on the proximal end of the shaft of the tibia. Fluores- 

 cent microscopy revealed a triple line of fluorescence. The amount 



