rRIST, MACDONALD, MOSS, AND SKOOG 



25 35 5 



DAYS POST INJECTION 



Fig. 9. Charts illustrating the retained amounts of Sr^^ and Ca^" as meas- 

 ured by whole body counting in Case No. 8. See Fig. 8. At all times, the 

 amounts of both isotopes retained by the skeleton were greater during treat- 

 ment with polysaccharide (first study) than with human growth hormone 

 (second study). The time required to lose 50 per cent of the Sr^^ ^^g 5 days 

 for the first study, as compared with 2 days for the second. 



of bone between the two inner lines represented the amount of bone 

 deposited during the period of 15 days of treatment with poly- 

 saccharide; the amount between the middle and outer lines, the 

 control period of 15 days of observation preceding treatment. The 

 distance between the two lines was approximately equal. In non- 

 osteoporotic control cases, the rate of bone formation decreased and 

 the space between the outer and inner lines diminished in the proc- 

 ess of closure of a labeled osteon. There was, however, considerable 

 variation between individual osteons. Some showed the diminishing 

 space between lines, and, therefore, no conclusive evidence of stimu- 

 lation of bone formation (Fig. 11). 



The histophysiologic changes observed in Case No. 7 were even 

 more extreme in Case No. 8. All sections showed many empty lacu- 



