412 



URIST, MACDONALD, MOSS, AND SKOOG 



Fig. 11. Fluorophotomicrograph of unckcalcified section of the proximal 

 end of the tibia in Case No. 8, illustrating triple labeling of an obliquelv cut 

 new osteon on the endosteal surface of the cortex. The space between the two 

 outer lines (i and 2) represents the amount of bone deposited during 15 days 

 on polysaccharide therapy, and the two inner lines (2 and 3) the control 

 period off therapy. The equal spacing, with due consideration for the diminish- 

 ing rate of deposition of bone, and the mean osteon formation time in this area 

 of the skeleton, suggests a slight beneficial effect of treatment on osteogenesis 

 in this case. 



