RAREFYING DISEASE OF THE SKELETON 



413 



TABLE I. Case No. 8, M. R.: Intravenous Injections 

 OF A Mixture of Sr^^ and Ca^' 



Treatment 



Polysaccharide 

 (Osseofac) 



Human growth hormone 



Tibia osteogram 



Knee osteogram 



Urinary excretion (3 days) 

 Total excretion (total body 



counting) : time to lose 



1st 50% of dose 

 Exchangeable calcium pool" 



From Sr**'^ data 



From Ca^^ data 

 Accretion rate for calcium" 



From Sr^^ data 



From Ca'*'' data 



Both Ca« and Sr«-^ still 

 rising after 70 minutes 



Both Ca^^ and Sr«^ still 

 rising after 70 minutes 



Sr, 23%; Ca, lost 



Both Ca^' and Sr«^ leveled 

 off after 15 minutes 



Both rising after 70 min- 

 utes but less steeply 



Sr, 37%;Ca, 14% 



Sr, 5 days; Ca, 18 days Sr, 2 days; Ca, 5 days 



1.9 gm 

 0.06 gm/day 



1.5 gm 

 5.9 gm 



0.04 gm/day 

 0.22 gm/day 



" Calculated by method of Eauer et al. (1961). 



Summary of Correlated Observations in Cases 7 and 8, 

 and Previous Six Cases of Severe Osteoporosis 



Table II includes previously tabulated data (Urist et al., 1962) 

 and data obtained from Cases Nos. 7 and 8. This table demonstrates 

 that correlation of the results of physiologic and morphologic meth- 

 ods of investigation was extremely valuable. The information gained 

 from one method tested the validitv of the other. Cases Nos. 7 and 

 8 (while receiving approximately the same amount of calcium as 

 there was in the diet to which they were accustomed) were in 

 negative calcium, phosphorus, and nitrogen balance. Case No. 7 was 

 restored to equilibrium or positive calcium balance by proline, but 

 tetracycline labeling showed no improvement in bone formation 

 rate or alteration of the course of osteoporosis. In Case No. 8, bal- 

 ance studies showed no improvement in calcium retention, while 

 the radioisotope osteograms revealed high or normal rates of uptake 

 of Sr^^ and Ca^' on polysaccharide therapy. The accretion rate cal- 

 culated by the Bauer et al. (1961) formulations was also higher. 

 The tetracycline uptake in new bone was approximately the same 



