400 



URIST, MACDONALD, MOSS, AND SKOOG 



Fig. 5F. Photomicrograph showing trabecular bone in severe osteoporosis. 

 The total number of trabeculae is low, and some are attenuated, but a few are 

 decreased in length and increased in thickness. The enlarging empty lacunae 

 and shrinking osteocytes are in the core (open arrow), while the living 

 osteocytes (black arrow) are on the surface. (X approx. 400.) 



tory studies showed no abnormality. The hiboratorv tests given Case 

 No. 7 were also given Case No. 8, and the results were all within the 

 limits of normal. 



Metabolic balance study. During a control period of 15 days, 

 the patient complained of backache and spent 20 hours a day in 

 bed. She lost weight and was in negative calcium, phosphorus, and 

 nitrogen balance. Polysaccharides (Dingwall et al., 1962; Westcott 

 et at., 1962 ) administered by intramuscular injection, 5 mg per day, 

 between the 15th and 30th days, did not prevent further decline in 

 weight, or change the calcium, phosphorus, or nitrogen balance. Hu- 

 man growth hormone (supplied by the Endocrine Study Section, 



