402 



URIST, MACDONALD, MOSS, AND SKOOG 



Flu. 511. Photomicrograph ilhistrating an enJargctl lacuna in hypermincr- 

 ahzed interstitial bone (arrow). This cell is also shown in Fig. 51. Osteocytes 

 with normal nuclei and lacunae of normal shape and size are found only in 

 perivascular lamellar bone. (X approx. 400.) 



reflect specific action upon either the skeletal svstem or the osteo- 

 porosis (Fig. 7). 



Radioisotope kinetic study. An intravenous injection contain- 

 ing 5 fjiC of Ca^', 5 fic of Sr^^, and 1 fxc of P^^ labeled serum albumin 

 was administered during the period of treatment with daily injec- 

 tions of polysaccharides extracted from bone, and again during the 

 period of treatment with human growth hormone. Osteograms of 

 the midshaft of the tibia during polysaccharide treatment showed 

 a slow change in rate of uptake, rising over a period of more than 



