RAREFYING DISEASP: OF THE SKELETON 



403 



Fig. 5 I. Microradiograph showing the identical area and osteocyte lacuna 

 (see arrow) illustrated in Fig. .5H. Note the hvpermineralized interstitial bone 

 and the low-density mineralized lamellar bone in the lower right osteon. The 

 sclerotic inner margin suggests that this osteon represents a deposit of old bone. 

 (X approx. 400.) 



1 hour; on treatment with human growth hormone, the rate of ac- 

 cumulation was the same as in normal subjects, where the accumula- 

 tion of the radioisotopes reached a plateau in 15 minutes. Other 

 areas of the skeleton responded in the same way as the tibia (Fig. 

 8). The daily loss of Sr^^ in the urine during treatment with poly- 

 saccharide, especially during the first 3 days, was less than with 

 human growth hormone. One-half of the Sr^° was excreted in 5 

 days when the patient received polysaccharides; on human growth 

 hormone, 50 per cent was excreted in only 2 days (Fig. 9). Ca^' 

 was much better retained in the skeleton than Sr" '. The 50 per cent 

 excretion point was reached after 18 days on polysaccharide treat- 

 ment but only 5 days on human growth hormone. This clearly 



