436 



URIST, MACDOXALD, MOSS, AND SKOOG 

 14% 



23% 



22% 



32% 



9% 



NON-FAT MILK 

 HIGH PROTEIN 

 DIET 



CORSET, 

 EXERCISE 



CALCIUM 

 GLYCERO- 

 PHOSPHATE 

 VITAMINE D 



SEX 



HORMONES 

 ANABOLIC 

 AGENTS & 

 NEW AGENTS 



• + - 



PLACEBO 

 PSYCHO- 

 THERAPY 



RESEARCH TO UNCOVER AN ANTIOSTEOPOROSIS OR BONE 

 RETENTION FACTOR 



Fig. 14. Diagrammatic illustration of the treatment recorded in the hospital 

 charts of 100 patients with severe osteoporosis over a period of 10 years. Nine 

 per cent changed their diet to include a higher intake of dairy food and protein; 

 32 per cent made some effort, in addition to the alterations in diet, to increase 

 the amount of physical exercise, and also to wear a corset for comfort; 22 

 per cent, especiallv those intolerant of dairy food, received calcium supple- 

 ments, chiefly calcium glycerophosphate, and maintenance doses (1000 lU) 

 of vitamin D; 23 per cent received sex hormones or anabolic steroids in ad- 

 dition to the above measures; 14 per cent received tranquilizers, muscle re- 

 laxants, vitamin B, and other drugs that had placebo effects in that there was 

 no detectable influence upon the skeletal system. No improvement in bone 

 density was observed by serial radiographs of the spine following any one, or 

 any combination, of these treatments. 



tion. The etiology of osteoporosis is not known. The disorder ap- 

 pears in its severest form much more frequently in females than in 

 males. Sedentary life after the menopause seems to be a factor. 

 Men and women who do heavy labor usually have spinal osteo- 

 phytes (spondylosis) and high bone density, whereas sedentary 

 individuals with osteoporosis generally are free of spondylosis and 

 have low bone density. Many patients with this disorder have the 

 normal capacity to produce new bone, but by some insidious mech- 

 anism all lose a large percentage of their bone mass in a relatively 



