()0'2 DOWSE, NEUMAN, LANE, AND NEUMAN 



TABLE VII. The Effects of Parathyroid Hormone 

 ON Lactate Production 



" Means ± standard error; numbers of flasks in parentheses. 

 * X2 and O2 contained 5 per cent CO2 for buffering. 

 -■Significant at /) < 0.001. 



In bicarbonate medium, the findings are obviously significant. The 

 absence or presence of ghicose and the level at which it is present 

 seem to be of no detectable importance. 



On the hvpothesis that the hormonal effect could well be time 

 dependent, longer incubation periods have been tried (Fig, 3A). A 

 continuing effect was observed, not increasing but rather decreasing 

 with time. Similarlv, with variation in concentration of the hormone, 

 a dose response curve is obtained (Fig. 3B). The response can no 

 longer be produced if the hormone is allowed to undergo inactiva- 

 tion bv being removed from the deep freeze for a few weeks. 



Conclusion 



Calvarium in these studies behaved qualitatively in a fashion simi- 

 lar to metaphyseal chips: low oxvgen consumption, excess reserve 

 succinate dehydrogenation capacitv, high glycolytic capacity, and. 



