PARATHYROID HORMONE AND RAT CALVARIA METABOLISM 



60.5 



0.5 I 1.5 



HOURS AFTER P' 



Fig. 4. The increased incorporation of labeled phosphate into the acid- 

 soluble esters of calvarium after parathyroid hormone. Newborn rat pups were 

 given 10 units Lilly Para-Thor-Mone each, or control injections, 30 minutes 

 prior to labeled phosphate. The size of the circles indicates the standard error 

 for each point. (Data taken from Egawa and Neuman, 1963.) 



Thus, it is our present opinion that explorations of carbohydrate 

 metabohsm have not yet yielded important clues as to the primary 

 sites of action of parathyroid hormone. Whether further exploration 

 of phosphate transport will prove more profitable, only time will 

 tell. 



Summary 



Calvaria from newborn rats were taken for biochemical study of 

 the action of parathyroid hormone for several reasons: responsive- 

 ness of the tissue, its low mineral-high cell content, its low marrow 

 contamination, and its ease of preparation with little cell damage. 



