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Fig. 40. Effects produced by hypophysectomy on the rat ovary and of replacement 

 therapy utilizing injections of pituitary gonadotrophins. (After Evans, Simpson, and 

 Penchaez: Symposia of Quantitative Biology, Vol. 5, 1937. The Biological Laboratory, 

 Cold Spring Harbor, L. I., N. Y.) (A) Ovary of hypophysectomized animal. Observe 

 that Graafian follicles are small. They do not proceed further in their development than 

 the beginning of antral vacuole formation unless replacement therapy is applied. (B) 

 Ovarian condition of hypophysectomized animal receiving replacement therapy in the 

 form of injections of the LH (ICSH) gonadotrophic factor of the anterior lobe of the 

 hypophysis. Interstitial tissue is well developed. (C) Ovarian condition of hypophysec- 

 tomized animal receiving the FSH gonadotrophic factor. Note follicular growth and antral 

 vacuole formation; interstitial tissue between the follicles remains somewhat deficient. 

 (D) Ovarian condition of hypophysectomized animal receiving injections of FSH plus 

 LH. Corpora lutea are evident (as well as enlarged follicles not shown in the figure). 

 Interstitial tissue remains deficient. 



69 



