74 



J. C. BiRKENHAGER, J. VAN DER SlUYS VeER, R. O. VAN DER HeUL, D. SmEENK 



In hyperparathyroidism the average hydroxyproline content of bone was about 

 the same as that of the controls, but in the former group the range was considerably 

 wider, 29.5 — 40.2 as compared to 31.6 — 35.7 //g per mg bone. The average phos- 

 phorus-hydroxyproline ratio (P/PH) was significantly lower in hyperparathyroidism 

 than in the controls. 



PHOSPHORUS 

 /jg/mg BONE 



HYDROXYPROLINE 

 >jg/mg BONE 



-t 



Fig. 1. Phosphorus and hydroxyproline content (and the 

 with hyperparathyroid. 



^HP 



r ratio) of iliac crest bone from controls and patients 

 sm. Averages ± S.D. 



B. Hyperadrenocorticism 



In the bone from seven cases of Cushing's syndrome and from two patients 

 treated with prednisone the percentage of tetracycline labelled surface varied from 



PHOSPiHORUS 

 /jg/mg BONE 



CONTROLS 

 13 



1021+ 32 

 MCUSHING 



HYDROXYPROLINE 

 /jg/mg BONE 

 40^ 



4 



MCUSHING 

 9 



CONTROLS 

 10 



Fig. 2. Phosphorus and hydroxyproline 

 with Cushing's syndr 



(and their ratio) of iliac crest bone from controls and patient 

 under prednisone treatment. Averages ± S.D. 



2 — 25Vo with an average of 14'*/o. The average phosphorus content of bone in 

 Cushing's syndrome or cases under prednisone treatment did not differ statistically 

 from that in the control group, whereas the average hydroxyproline content appeared 



