206 J.-F. Dymling: Therapeutic Results in Renal Tubular Osteomalacia 



Summary 



Kinetic studies with -^'Ca or ^''Sr have been performed in three cases of renal 

 tubular osteomalacia in the untreated state and during oral treatment with sodium 

 monophosphate and sodium monophosphate plus vitamin D. The accretion rates were 

 high in the untreated state. They were increased by phosphate supplements, but even 

 more increased by phosphate supplements plus vitamin D. The kinetic changes have 

 been interpreted as signs of healing, which was supported by the observed clinical 

 and radiographic improvement. 



Acknowledgements 

 Financial support was obtained from the Herman Jarnhardt Foundation, Malmo, 

 and from grants to G. C. H. Bauer from the International Atomic Energy Agency 

 and United States Public Fiealth Service grant D-1452. 



References 



Albright, F., A. M. Butler, and E. Bloomberg: Rickets resistant to vitamin D therapy. 



Amer. J. Dis. Child. 54, 529 (1937). 

 Bauer, G. C. H., A. Carlsson, and B. Lindquist: Bone salt metabolism In human rickets 



studied with radioactive phosphorus. Metabolism 5, 573 (1956). 

 Dymling, J.-F.: Calcium kinetics In osteopenia and parathyroid disease. Acta med. scand. 



175, suppl. 408 (1964). 

 Engfeldt, B., R. Zetterstrom, and J. Winberg: Primary vltamln-D resistant rickets. 



Ill Biophysical studies of skeletal tissue. J. Bone Jt Surg. 38 A, 1323 (1956). 

 Falkson, G., and B. Frame: Phosphate diabetes. Henry Ford Hosp. Bull. 6, 244 (1958). 

 Fanconi, G., and P. Girardet: Familiare perslstierende Phosphatdlabetes mit D-vItamln- 



reslstenter Rachitis. Helv. paedlat. Acta 7, 14 (1952). 

 Frame, B., A. R. Arnstein, H. M. Frost, and R. W. Smith, Jr.: Resistant osteomalacia. 



Amer. J. Med. 38, 134 (1965). 

 — , and R. W. Smith: Phosphate diabetes. A study of osteomalacia. Amer. J. Med. 5, 771 



(1958). 

 Eraser, D., D. W. Geiger, J. D. Muhn, P. E. Slater, R. Jahn, and E. Liu: Calcification 



studies In clinical vitamin D deficiency and In hypophosphatemic vitamin D-rcfractory 



rickets. Amer. J. DIs. Child. 96, 460 (1958). 

 Frost, H. M.: Some observations on bone mineral In a case of vitamin D-resIstant rickets. 



Henry Ford Hosp. Bull. 6, 300 (1958). 

 Kuhlencordt, F.: Die glucosurlsche Osteopathic. Ergebn. Inn. Med. KInderhellk. 9, 622 



(1958). 

 Lafferty, F. W., C. H. Herndon, and O. H. Pearson: Skeletal dynamics In vitamin D 



resistant rickets. In Dynamic Studies on Metabolic Bone Disease. Pearson, O. H., and 



JoPLiN (eds.). Oxford: Blackwell Scientific Publications 1964. p. 163. 

 Meltzer, W., I. Lyon, E. D. Mensen, and R. D. Ray: Radioisotope studies of generalized 



skeletal disorders. Clin. Orthop. 17, 269 (1960). 

 Pierce, D. S., W. M. Wallace, and C. H. Herndon: Long-term treatment of vltamln-D 



resistant rickets. J. Bone Jt Surg. 46 A, 978 (1964). 

 Tapia, J., G. Stearns, and I. V. Ponseti: Vitamin-D resistant rickets. J. Bone Jt Surg. 46 A, 



935 (1964). 

 Williams, T. F., R. W. Winters, and C. H. Burnett: Familial hypophosphatemia and 



vitamin D-resIstant rickets. In the Metabolic Basis of Inherited Disease. Stanbury, Wyn- 



gaarden, and Fredrickson (eds.). New York: McGraw Hill 1960, p. 1177. 



