Bony Targets of Non-"skeletal" Hormones 225 



the late effects of parathyroid extract on bone metabolism — an example of "per- 

 missive" effects of these hormones in bone which appears to be confirmed by recent 

 experiments in our laboratory. 



In closing a few general remarks seem in order. Clearly the whole subject of 

 effects of "non-skeletal" hormones on bone while once popular has been passing 

 through a period of partial eclipse during which only the clinician, faced as he 

 always is with the need to aleviate the distresses of the sick, has maintained an inter- 

 est in how these substances may modify skeletal behavior. During the same time new 

 views in endocrinology, based in biochemistry and cellular physiology, have been 

 developing which provide new insights into the fundamental modes of action of 

 many hormones. While these have yet to be applied systematically to bone, the need 

 to do so is obvious; the way to pursue such studies seems clear; and all that is needed 

 now is to get to work. 



Acknowledgements 



Unpublished work quoted in this communication was supported by grants from 

 the National Institutes of Health, USPHS. The technical assistance of H. Alstrup, 

 N. Steinberg, S. Ault and R. Smith is gratefully acknowledged. 



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