The Effect of Cortisone and Anabolic Agents on Bone 



247 





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Fig. 2. 16 days of cortisone administration 

 capillaries penetrate to the normal level of the 

 Sealing of the cartilage by a horizontal plate of 



an abnormal appearance, small 

 and heavily stained. Resorption 

 seemed to have come to a halt, 

 and the appearance of the bone 

 showed very little alteration with 

 continuous cortisone administration 

 for up to 6 weeks. 



4. The sinusoid walls and sur- 

 faces of the cells in the bone and 

 marrow had an irregular appear- 

 ance, in contrast to the sharp out- 

 lines observed in control sections 

 prepared under the same condi- 

 tions. That these cells have their 

 surface structure disturbed pro- 

 vides a probable explanation for 

 the changed sinusoids and the re- 

 laxation of the cell walls which 

 may initiate the first stages of 

 osteoclast formation. In connective 

 tissue cells the channels along which 

 chromatin precursors travel to the 

 nucleus appear to be continuous 

 with the surface membranes of the 

 cells, as described by Rigal and 

 Little (1962). A disturbance of 

 the walls of such channels leading 

 transport of materials needed for ce 



iwi'd h\ 3d.i\s ot tortisoiif pin-. "St i miilvi ". I'la- metaphyseal 

 growth plate leaving behind an area of arrested cartilage cells, 

 bone as produced by the cortisone alone is clearly demonstrated 



Fig. 3. 7 days cortisone alone followed by 14 days cortisone 

 plus "Stromba". Further penetration of the vessels and re- 

 sumption of endochondral ossification 



to the nucleus could prevent adequate surface 

 11 division. 



