634 



XIII. HEMOGLOBIN AND PORPHYRIN SYNTHESIS 



closure of glutamic acid to pyrrolidonecarboxylic acid, von Euler 

 {70Ji) the condensation of isoprene or methylcrotonaldehyde with 



Fig. 2. Theory of porphyrinogenesis of Rimington and Dobriner (J9S6). 



ammonia or (712) the ring closure of polyenes with ammonia, Emde 

 {684) condensation of ammonia with furfuraldehyde, Whipple and 

 Robscheit-Robbins {3062) ring-closure of straight-chain amino acids. 

 Glucosamine has been tested by Kench {1514), who found large 

 amounts, given to patients with acute porphyria, unable to increase 

 porphyrin formation. 



