of giant Diptera chromosomes to gene activation (see Cliapter 4, Fig- 

 ures 4-19 and 4-20). Also one may look for critical changes in the re- 

 lationship of chromosome, nuclear boundary, and endoplasmic reticulum 

 which may be correlated with differential transfer of genetic information 

 (Gay, 1956) (Figure 4-3). Although so far, few studies have been con- 

 sciously aimed in this direction, the rapid welding of subcellular structure 

 and cellular biochemistry makes it inevitable that a sort of subcellular 

 cytogenetics will soon evolve. 



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