EFFECTS OF EXTRACTS OF PARS NEURALIS 



sympathetic, cause a deposition of fat in the hver. Before 

 other aspects of Raab's hypothesis require examination, it is 

 necessary to inquire how generally and how consistently 

 others have observed a fall in the blood-fat concentration 

 after the injection of a posterior-lobe extract. The injection 

 of posterior-lobe extract into the dog was followed by a de- 

 crease in the concentration of neutral fat or fatty acids in the 

 blood (experiments of Bhx and Ohlin, 1927, and of Nitzescu 

 and Benetato, 1930). In the experiments of Himwich, 

 Haynes, and Spiers (1928) who injected posterior-lobe ex- 

 tract, the oxytocic principle, or the vasopressor principle into 

 dogs, the results were irregular; posterior-lobe extract usually 

 caused a reduction in the concentration of the blood fat. All 

 investigators agree that posterior-lobe extract has no effect 

 on the blood fat of the rabbit (Blix and Ohlin, 1927; George, 

 1930; and Long, Hill, and Bischoff, 1932). 



Rabb also concluded that the fat-metabolism center of 

 obese human beings is unresponsive to posterior-lobe extract. 

 Furthermore, he believed that posterior-lobe extract causes a 

 reduction in the concentration of blood-fat in alimentary 

 lipemia. However, no effect was observed by Rony and 

 Ching (1930), who administered to fasting dogs 4.4 cc. of 

 olive oil per kilogram body-weight with or without an injec- 

 tion of posterior-lobe extract. 



365 ] 



