EFFECTS OF EXTRACTS OF PARS NEURALIS 



1920; Fromherz, 1923; Molitor and Pick, 1924; McFarlane, 

 1926; xAdolph and Ericson, 1927; Haldane, 1928; DanilofF, 

 1934; and Nelson and Woods, 1934). 



Various phases of the metabolism of water (usually of 

 excess water) have been studied.'' Water-intoxication has 

 been mentioned already. McQuarrie and Peeler (1931) found 

 that grand mal seizures could be provoked in children with 

 latent or mild epilepsy by the repeated administration of 

 water and sufficient posterior-lobe extract to cause diuresis 

 inhibition. Usually the administration of water and posterior- 

 lobe extract is followed by evidence of hydremia. Even with 

 clear-cut diuresis inhibition, however, the change may be 

 slight. The relative increase in the amount of water is slighter 

 in the tissues but has been observed in the skin and striated 

 muscle.'" 



Diuresis inhibition and its associated phenomena following 

 the injection of posterior-lobe extract appear to be best ex- 

 plained as the results of renal effects. Evidence that extra- 

 renal factors are important is so far inconclusive. It is 

 thought, on the one hand, that direct tissue effects may occur. 

 On the other hand, Molitor and Pick (1925-26, 1930), be- 

 lieved that in the presence of excess water, a water center in 

 the diencephalon is stimulated with resulting diuresis; if, 

 however, posterior-lobe extract is administered, diuresis is 

 inhibited because of the extract's effect on the water center. 

 In favor of a direct tissue effect it has been reported that the 

 injection of posterior-lobe extract causes an increase (10-15 

 per cent) in the concentration of chloride in the blood of the 

 nephrectomized rabbit (Miura, 1925; Buschke, 1928). The 



» See also the experiments of Ballinari (1929); Klein (1930); Kiss (1931); Man- 

 chester (1932); Adiersberg and Paul (1933); and Czika (1933). 



"See Bayley and others (1922); Weir and others (1922); Lamson and others 

 (1923); Weir (i923);Hines and others (1927-28); Kucharski (1927); Leese and oth- 

 ers (1927); Raab (1928); Brednow (1931); Friedrich (1931); Roboz (1931); 

 Heller and Smirk (1932); Robert (1932); Smirk (1933); and Wada (1933). 



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