EFFECTS OF EXTRACTS OF PARS NEURALIS 



1923; Elkeles, 1926; man: Hoffmann, 1921; Schoendube and 

 Kalk, 1925-26; Cascao de Anciaes, 1926). '•^ 



Dodds, Noble, and Smith (1934) reported that large doses 

 of posterior-lobe extract or of the vasopressor principle (200- 

 800 units subcutaneously; 600 units by mouth), administered 

 to rabbits, cause hemorrhagic necrosis and ulceration of the 

 mucous membrane of the stomach. In addition, there may 

 occur a marked anemia which cannot be accounted for solely 

 by the gastric hemorrhages (Dodds and Noble, Dodds and 

 others, 1935). Bergami (1935) found that posterior-lobe ex- 

 tracts or the vasopressor principle may cause, in the rat and 

 rabbit, hemorrhagic lesions in the mucous membrane of both 

 the stomach and the lungs. 



Miscellaneous ejects. — Nikolaeff (1929) reported that pos- 

 terior-lobe extract caused an increased liberation of epi- 

 nephrin from the perfused adrenal gland of the ox. 



There is disagreement as to the effects of the oxytocic and 

 the vasopressor principles on the coagulation of the blood 

 (Curtis and Pickering, 1928; La Barre and Patalano, 1930; 

 and Nitzescu, 1930). 



Rogers (1921, 1926) found that the injection of a posterior- 

 lobe extract into pigeons in which the optic thalamus had 

 been destroyed after the removal of the hemispheres caused 

 a considerable rise in the body temperature. After the injec- 

 tion he also could readily cause a fatal reflex cardiac inhibi- 

 tion by stimulating the cloaca, oviduct, etc. 



Observations on the metabolism of the active principles. — The 

 oxytocic principle may be absorbed from the stomach or 

 duodenum (Rees and Whitehead, 1923; Hansen and Burnett, 

 1930). The intravenous injection of the pressor principle 

 into sheep during the second half of pregnancy may cause 

 some elevation of the fetal blood pressure (Cattaneo, 1933). 



Knaus (1925) found that the pressor effect in comparison 

 with the oxytocic effect of a posterior-lobe extract was much 



'3 See also Namba-Kiichi (1928). 



[349] 



