THE PITUITARY BODY 



by luteinization of both the granulosa and the theca interna. 

 Other investigators also have observed the effects of im- 

 plants or extracts on the ovaries of the immature guinea pig 

 (ox pituitary: Brouha and Simmonet [1928]; Aron [1931]; 

 and Guyenot and others [1933]; sheep pituitary: Guyenot 

 and Ponse [1932]; and King [1933]). 



In adult female guinea pigs, extracts of the anterior lobe of 

 the ox bring about atresia of the follicles, prohferation of the 

 theca interna, and the formation of interstitial gland tissue 

 (Aron, 193 1 ). Guyenot and others (1932-33) found that ex- 

 tracts of the ox gland not only produced theca-luteinization 

 but also a hypertrophy of the clitoris. They stated that the 

 latter effect could be observed in adult female guinea pigs 

 even after ovariectomy. 



Guyenot and his co-workers (1933) described a hypertro- 

 phy of the secondary sexual characters in immature male 

 guinea pigs into which they had injected an alkaline extract 

 of the anterior lobe of the ox. Moszkowska (1935) believed 

 that atrophy of the penis took place more slowly or that some 

 hypertrophy of the penis even occurred if an anterior-lobe 

 extract was injected into mature or immature guinea pigs 

 shortly after castration. 



3. The rabbity cat, and ferret. — The peculiarity in the physi- 

 ology of the reproductive organs in these three mammals is 

 the fact that ovulation ordinarily does not occur except after 

 coitus. The most complete studies (and this is also true of 

 gonadotropic hormones) have been made in rabbits. Rabbits 

 normally ovulate about 10 hours after coitus; ferrets, about 

 30 hours; cats probably ovulate less than 25 hours after coitus 

 (Greulich, 1934). 



The effect of hypophysectomy on ovulation in the rabbit 

 has already been discussed in chapter ii. It will be recalled 

 that if the operation is performed less than i hour after copu- 

 lation, ovulation does not occur. On the other hand, normal 

 ovulation takes place in rabbits hypophysectomized later 



[134] 



