THE PITUITARY BODY 



some instances, the pseudopregnant reaction of the uterus 

 persisted longer than the corpora lutea. On the other hand, 

 the repeated injection of an anterior-lobe extract might be 

 accompanied by ovarian luteinization and pseudopregnant 

 changes in the uterus; however, after a week, the oxytocic 

 hormone often produced a uterine contraction even after the 

 additional injection of a potent extract of the corpus luteum. 



It is reasonably certain that the dose of an anterior pitui- 

 tary extract required to produce ovulation is much greater in 

 the cat than in the rabbit (Snyder and Wislocki, 1931; Good- 

 man and Wislocki, 1933; unpublished experiments of the 

 author). Courrier and Kehl (1929) injected (but not intra- 

 venously) extracts of the anterior lobe repeatedly into cats. 

 Small doses of the extract produced cystic follicles; large 

 doses produced corpora lutea atretica. 



McPhail (1933) has produced ovulation in the ferret in 

 oestrus. In earlier work, Hill and Parkes (1930) produced 

 cystic follicles in the ovaries of ferrets into which they in- 

 jected an anterior-lobe extract repeatedly. In hypophysec- 

 tomized ferrets, extracts seem to bring about a luteinization 

 of the theca interna of small follicles, but no follicular 

 growth (McPhail, 1933). 



4. The dog^ ground-squirrel, and whale. — The gonads of the 

 dog (like other mammals) are not affected by the feeding of 

 the pars glandularis (Novak and Kun, 1931). Reichert (1928) 

 administered fresh whole rabbit pituitary daily to a hypophy- 

 sectomized dog (6 months after hypophysectomy which was 

 performed when the puppy was about 6 weeks old). Swelling 

 of the vulva appeared within 48 hours, and was marked after 

 72 hours. There was considerable secretion in the vagina 2 

 weeks after the hetero-implants were started; after that, a 

 pronounced vaginal secretion was observed as long as the im- 

 plants were continued. In normal dogs, the administration 

 of an extract of the anterior lobe of the ox has caused hyper- 

 trophy of the ovary, uterus, and vagina (Benedict, Putnam, 



[138] 



