THE PITUITARY BODY 



found that the subcutaneous injection of 8-10 cc. of the blood 

 of a starved normal dog into a rabbit (1.5-2.0 kg.) was fol- 

 lowed by a reduction in the concentration of blood sugar 

 amounting to 5 per cent; under similar conditions, a greater 

 reduction (23 per cent) in the concentration of the blood 

 sugar followed the injection of the blood of a hypophysec- 

 tomized dog. This report was not confirmed by Di Benedetto 

 (1934), who injected as much as 20 cc. of blood. 



The administration of glucose, by stomach-tube or paren- 

 terally, on the other hand, is usually said to modify the gly- 

 cemic curve of hypophysectomized dogs in the direction of a 

 greater change (increase) and a slower return to normal 

 (Klug, 1928; D'Amour and Keller, 1933; Lucke, Heydemann, 

 and Hechler, 1933; Biasotti, 1934). (Some have stated either 

 that the curve is normal or perhaps rises more slowly [Hous- 

 say and Hug, 1921; Houssay, Hug, and Malamud, 1922; 

 Sachs and MacDonald, 1925].) Only Fujimoto (1932) found 

 that less elevation of the glycemic curve occurred in hypo- 

 physectomized dogs. Both he, and Lucke and others, reported 

 that the glycosuria following the administration of glucose 

 was less in hypophysectomized dogs than in normal dogs. 



The amount of glycogen in the liver and in striated muscle 

 is said not to be affected by hypophysectomy (Aschner, 191 2; 

 Houssay, Hug, and Malamud, 1922). Yet epinephrin pro- 

 duces less elevation of blood sugar and less glycosuria in 

 operated animals (Aschner, 1912; Fujimoto, 1932). Such 

 changes do not necessarily indicate a decreased sensitivity of 

 the sympathetic nervous system, as Aschner thought, but 

 may be due to an increased rate in the metabolism of glucose 

 or to other causes. 



The administration of phlorhizin to hypophysectomized 

 dogs, in comparison with normal dogs, brings about the fol- 

 lowing changes (Houssay and Biasotti, 1931; Biasotti and 

 Houssay, 1932; Rietti, 1932): (i) death frequently occurs, 

 the blood-sugar concentration being less than 70 mg. per 



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