THE PITUITARY BODY 



stated that the specific dynamic action of glycocoll, admin- 

 istered by intraperitoneal injection, was abolished by total 

 hypophysectomy but not by the removal of either the an- 

 terior or the posterior lobe alone. 



The growth of the Walker mammary-gland carcinoma in 

 hypophysectomized and normal rats was investigated by 

 Ball, Samuels, and Simpson (1932), Samuels, Ball, and Simp- 

 son (1933), and McEuen (1933). The rate of growth of the 

 tumor was slower, but the area of necrosis in the tumor was 

 greater in the transplants in hypophysectomized rats. These 

 findings suggest that the tumors growing in the hypophysec- 

 tomized rats were less adequately vascularized than those 

 growing in the normal rats. Reiss, Druckrey, and Hochwald 

 (1933) transplanted the Jensen-sarcoma into young rats be- 

 fore and after hypophysectomy. The operation had striking 

 effects on the growth of this tumor. The removal of all the 

 pituitary body from tumor-bearing animals (provided that 

 the tumor was smaller than a cherry in size) or the successful 

 transplantation of the tumor into hypophysectomized ani- 

 mals was followed by some growth of the sarcoma; however, 

 within 3 weeks, the tumor retrogressed especially in animals 

 losing weight. The retrogression occurred earlier if the tumor 

 was transplanted into rats some months after hypophysec- 

 tomy. 



The ejects of hypophysectomy in the dog. — Since Horsley's 

 (1886) first observations on experimental hypophysectomy in 

 the dog, the literature has contained numerous reports of the 

 effects of the removal of the pituitary. The difiiculty of the 

 operation is reflected in the discordant results of different 

 investigators. If the number of papers published be accepted 

 as a guide, more attention has been given to hypophysectomy 

 in the dog than in any other animal. Horsley's dogs lived in 

 apparently normal health for months after the removal of the 

 pituitary — an observation which Handelsmann and he (191 1) 

 repeated a quarter of a century later. Paulesco (1907), how- 



[58] 



