ANATOMY OF THE PITUITARY BODY 



cytoplasm rapidly disappeared. Piccone (1933) found that 

 the pituitary of the lactating guinea pig resembled that of the 

 pregnant animal. 



The pituitary after spaying or castration. — Tandler and 

 Gross (1908) examined, by means of X-ray photographs, the 

 sella turcica of castrated men. They observed enlargement 

 of the sella, due, they believed, to a hypertrophy of the pitui- 

 tary. In the same year Kon studied the pituitaries of a cas- 

 trated man and several spayed women. He concluded that 

 the hypertrophy, if present, was the result of hyperplasia of 

 the chromophil cells of the pars glandularis. In most of 

 Kon's cases there seemed to be an increase in the number of 

 oxyphils, although in two the basophils also were "especially 

 well developed." In the castrated man there seemed to be a 

 hypertrophy of the reserve cells. Rossle's report (1914) is 

 based on the study of a large number of human pituitaries of 

 which twenty-eight were from women spayed one week to 

 sixteen years previously. According to Rossle, hypertrophy 

 of the pituitary after spaying is less constant than a histo- 

 logical alteration of the pars glandularis. The latter consists 

 chiefly of an increase in the number as well as the sites of 

 formation of oxyphils. However, Rossle did not find such 

 changes constantly nor did he believe that they were specifi- 

 cally related to ovariectomy. In a recent report, dealing in 

 part with the histology of the pituitary of ten spayed women 

 (mostly ovariectomized, but some previously treated by 

 X-rays or radium), Philipp (1930) described a marked in- 

 crease in the number of oxyphils as well as a similar change 

 in the amount of colloid. Kraus (1932) also was of the opin- 

 ion that the proportion of oxyphils in the pituitary is in- 

 creased after gonadectomy in man. 



The widely quoted work of Fichera (1905) was the first 

 dealing with the eff^ect of gonadectomy on the pituitary of 

 animals. He concluded that the pituitary became larger and 

 was made up of an increased number of oxyphil cells after 



[23] 



