PARS INTERMEDIA AND PARS TUBERALIS 



made. Using the isolated frog skin as a test object, he found 

 that the pars intermedia contained the highest concentration 

 of the hormone. The colloid of the ox-pituitary also contains 

 the hormone(s) affecting the chromatophores (Smith and 

 Smith, 1923; Zondek and Krohn, 1932). 



Zondek and Krohn (1932) as well as Jores and Will (1934) 

 agreed that the highest concentration of the erythrosome- 

 dispersing hormone {Phoxinus) is found in the pars inter- 

 media (ox). However, Jores and Will believed that the 

 melanosome-dispersing hormone (isolated frog skin) is pres- 

 ent in the basophil area (Smith) of the pars glandularis in 

 slightly greater concentration than in the pars intermedia.'^ 

 Their other results dealing with the distribution of the eryth- 

 rosome-dispersing hormone do not agree with those of Zondek 

 and Krohn. 



The pituitary of the pregnant woman contains the melano- 

 some-dispersing hormone, but little or no gonadotropic hor- 

 mone (Ehrhardt, 1932; Zondek and Krohn, 1932). The pars 

 intermedia of the human adult is at most a rudimentary 

 structure. According to Roth (1932), the human pars glan- 

 dularis is richer in melanosome-dispersing hormone than the 

 "intermedia-zone" or the pars neuralis. He concluded that 

 the basophil cells of the pars glandularis secrete the hormone. 

 Jores and Glogner (1933) found that the concentration of the 

 hormone was especially high in the basophil adenoma (pars 

 glandularis) and low in the reserve-cell adenoma. 



In the pituitary of the whale the erythrosome-dispersing 

 principle is found in the pars glandularis but not in the pars 

 neuralis (Valso, 1934). 



2. The distribution in tissues and body fluids of substances 

 causing erythrosome dispersion in Phoxinus or melanosome 

 dispersion in the skin oj the frog. — According to Zondek and 



'3 Jores is of the opinion that melanosome-dispersion (frog skin) is due to a 

 hormone different from that causing erythrosome-dispersion {Phoxinus). See the 

 later discussion. 



