THE EFFECTS OF HYPOPHYSECTOMY 



in the urine, as did the addition of posterior-lobe extract to 

 blood which otherwise was without effect. He also concluded 

 that this effect was not observed after hypophysectomy. In 

 criticism of Verney's experiments it may be pointed out that 

 the effect of a lesion of the tuber cinereum was not investi- 

 gated.''' Moreover, Fee (1929) has questioned the validity of 

 conclusions drawn from such a use of the isolated kidney. In 

 the acute experiments of Brull and Eichholtz (1925), hypo- 

 physectomy or injury of the wall of the third ventricle abol- 

 ished the normal secretion of inorganic phosphate in the 

 urine. This effect occurred independently of the rate of the 

 renal secretion of water or chloride. 



The relation between the hypothalamus and the metabolism of 

 carbohydrates. — In both dogs and men with lesions of the 

 hypothalamus, a glycosuria may appear. Experimentally, 

 however, it has been noted much less frequently than poly- 

 uria, and is usually more transient.'^ D'Amour and Keller 

 (1933) reported that after the administration of glucose by 

 stomach tube, hyperglycemia and high or prolonged glycemic 

 curves might occur in dogs in which a bilateral transverse 

 lesion had been made at the level of the optic chiasm. Simi- 

 larly, Biasotti (1934) stated that after the intravenous injec- 

 tion of glucose, the concentration of sugar in the blood re- 

 turned to its former level more slowly in dogs with lesions of 

 the tuber cinereum than in normal dogs. The changes re- 

 ported by these authors resemble those in hypophysecto- 

 mized dogs, but are less pronounced. These effects of hypo- 



'^ According to Bourquin (1927-29), diuresis can be produced by extracts of the 

 blood and the urine as well as of the hypothalamus of dogs with diabetes insipidus 

 after an injury of the hypothalamus. She stated that this effect could also be pro- 

 duced by extracts of the hypothalamus (corpora mammillaria) of normal dogs. 

 Trendelenburg concluded that Bourquin's extracts would have produced diuresis- 

 inhibition in unanaesthetized animals (i.e. produced effects like posterior-lobe 

 extract). 



■' Besides the references of the preceding section, see Sachs and MacDonald 

 (1925); Pickat (1927); and Houssay and Biasotti (1931). 



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