THE PITUITARY BODY 



times in animals killed in the succeeding dioestrus when the 

 uterus is not distended by fluid (see Fig. 29). 



Immature mice in which implants of the anterior pituitary 

 have caused sexual maturity will mate (Smith and Engle). 



^^1^!!S^. 



^^f^^.^^A- 





Fig. 29. — Photomicrographs of the uteri f X24) and the vaginal mucosae (X200) 

 of httermate rats, the ovaries of which are shown in Figure 28. Top, of normal rat. 

 Middle, of rat receiving 2 mg. of extract. Bottom, of rat receiving 6 mg. of extract. 



Implants of the anterior pituitary of immature, adult, and 

 senile rats are about equally effective in producing a preco- 

 cious sexual maturity (Smith and Engle). On the other hand, 

 the implantation of anterior pituitary tissue into senile mice 

 will cause oestrus and the formation of corpora lutea (Zondek 



[114] 



