THE PITUITARY BODY 



Reichert and his co-workers (1931, 193-) reported that pro- 

 lan (unHke heteroplastic pituitary implants, etc.) was with- 

 out effect on the ovaries of the hypophysectomized dog. 



;-., ...■/',._. •. ^\^» 4T!;;H^ * '-^ 







Fig. 39. — The effect of prolan on the testis of the hypophysectomized mature 

 rat. From Smith and Leonard (1934). Left: Photomicrograph of testis of unin- 

 jected rat 20 days after hypophysectomy. Right: Photomicrograph of testis of 

 injected rat 20 days after hypophysectomy. This rat received 25 rat-units of pro- 

 lan daily throughout the period following operation. Replacement therapy during 

 this period was complete inasmuch as mating between this male rat and two females 

 was fertile. 



THE POTENTIATION AND ANTAGONISM OF PROLAN EFFECTS 



The potentiation of prolan effects. — If an extract of the an- 

 terior pituitary and prolan are simultaneously administered 

 to mice or rats, the ovarian hypertrophy is much greater 

 than would be expected from a mere addition of effects. The 

 explanation of this potentiation of the effect of prolan is still 

 a matter of controversy. Evans and his co-workers^-' at first 

 believed that the growth-promoting hormone of the anterior 



^3 Evans, Meyer, and Simpson (1932), and Evans, Simpson, and Austin (1933). 



