THE PITUITARY BODY 



Niirnberger, Madruzza (1932), Inchara, Schenck (1933), and 

 Geyer (1934). On the other hand, the administration of 

 cortical extract or adrenalectomy 12 hours prior to the first 

 injection did not alter the luteinizing effect of prolan in im- 

 mature rats (Hicks and Matters, 1935). Engel (1934, 1935) 

 reported that alkaline extracts of dried epiphysis, if ad- 

 ministered with prolan, prevented such characteristic effects 

 as corpus luteum formation and stimulation of Leydig's cells. 

 According to Richter (1934), gonadectomized rats which 

 drank water containing pregnancy-urine were more active; 

 the size of the thymus of such animals was similar to that 

 of normal animals but much smaller than that of gonadecto- 

 mized rats which had drunk water not containing pregnancy- 

 urine. 



OTHER EFFECTS OF PROLAN 



There is no convincing evidence that prolan alters the 

 basal metaboHc rate. Crude preparations of prolan cause 

 hyperglycemia (Bohm, Eidelsberg, 1932); purer preparations 

 tend to cause hypoglycemia (Dingemanse and Kober, 1933). ''^ 

 Cannavo and Indovina (1932, 1933) believed that the concen- 

 tration of magnesium in the serum was elevated following 

 the injection of prolan. In rats and mice rendered anoes- 

 trous by thallium-poisoning, prolan caused the reappearance 

 of oestrus at least once (Bickel and Buschke, 1933)- Vitamin 

 deficiency (C and E) was not lessened by the administration 

 of prolan (Agnoli, 1932; Diakov and Krizenecky, 1933), nor 

 did vitamin E cause precocious sexual maturity. 



Zondek, Zondek, and Hartoch (1932) as well as Moller 

 (1933) found that the injection of large amounts of prolan 

 into mice into which Ehrlich's adenocarcinoma had been 

 transplanted markedly inhibited the growth of the tumor 



^7 Also see Houssay and Biasotti (1933); Davis, Hinsey, and Markee (1934); 

 and Hrubetz (1935). 



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