THE GROWTH-PROMOTING HORMONE 



of the way in which they were altered as a result of the injec- 

 tion of growth-promoting hormone. The hormone restored 

 the skin to normal (after operation, it was atrophic). The 

 hormone also augmented the rate of hair-growth to normal 

 and increased the weight of hair per unit surface to as much 

 as one-fourth above that in normal rats. 



The effects of extracts containing the growth-promoting 

 hormone have been investigated in several races of dogs.^ 

 The prominent general effects in growing puppies or dogs 

 otherwise normal are the following: symmetrical overgrowth 

 of the skeleton and soft parts,^ including a marked folding of 

 the skin; splanchnomegaly including hyperglossia; various 

 symptoms such as hypotonia (the stance may be plantigrade 

 instead of digitigrade), asthenia, polyphagia, polydipsia, 

 polyuria, and sialorrhea. Emaciation may or may not be as- 

 sociated with glycosuria and hyperglycemia (diabetes melli- 

 tus may be diagnosed). Whether or not all these signs and 

 symptoms are to be attributed only to the growth-promoting 

 hormone is not known. 



In Figure 27, photographs of two of the pure-bred Dachs- 

 hunde of Evans, Meyer, Simpson, and Reichert are repro- 

 duced. One of these littermate males (No. 3) had received 

 injections of a growth-promoting extract over a period of 6 

 months. As a result, the weight was markedly increased (con- 

 trol, 10.9 kg., injected, 17. i kg.). The changes in the skin and 

 soft parts are evident. By means of roentgenograms, definite 

 increases in the size of the skull and bones could be demon- 

 strated. The short extremities of the Dachshund^ which the 

 authors, following Stockard, consider to be due to an achon- 

 droplasia, were not affected by the treatment. 



^Putnam, Teel, and Benedict (1928); Reichert (1929); Benedict, Putnam, and 

 Teel (1930); Downs (1930); Teel and Gushing (1930); Evans, Meyer, Simpson, 

 and Reichert (1932-33); Reichert, Simpson, Cornish, and Evans (1933). 



1 Changes in the jaw and skull may be relatively greater in the bulldog — an 

 exaggeration of what is normal in this race. 



[91] 



