THE PITUITARY BODY 



one or two injections of the tissue-fluid of 3-12 anterior lobes 

 of the ox. 



A number of authors have found no difficulty in producing 

 ovulation in pregnant rabbits by injecting (subcutaneously, 

 intramuscularly, or intravenously) extracts of the pars glan- 

 dularis (Loeser, 1930; Wolfe, 1930; Snyder and Wislocki, 

 1 93 1; and others). Wislocki and Goodman (1934) produced 

 unusual numbers of hemorrhagic follicles and corpora lutea 

 by intravenous injections of anterior-lobe extract (ox) into 

 rabbits after copulation and ovulation. Despite this treat- 

 ment, implantation was not delayed and pregnancy was not 

 interrupted. 



The gonadotropic hormone{s) in relation to other glands of 

 internal secretion, vitamins, etc. — Several authors have sug- 

 gested that the growth-promoting hormone antagonizes the 

 effects of the gonadotropic hormone(s) (e.g., Evans and 

 Simpson, 1928). However, Targow concluded that growth- 

 promoting hormone did not lessen the secretion of gonado- 

 tropic hormone by the pituitary of young castrated rats. 

 Leonard (1934) found that the gonad-stimulating effect of 

 prolan could be inhibited by the intraperitoneal injection of 

 extracts of the pars glandularis of the ox but that this effect 

 probably was not related to the growth-promoting properties 

 of the extracts. 



There is clinical evidence of an interrelationship between 

 the adrenal cortex and the gonads. xAlso, there is some ex- 

 perimental evidence that the pars glandularis — by means of 

 its gonadotropic hormone(s) — may participate in such a pos- 

 sible interrelationship. According to Shumacker and Firor 

 (1934) a moderate atrophy of the gonads is observed in adre- 

 nalectomized rats. This atrophy can be repaired by the ad- 

 ministration of pituitary implants. Moreover, the pituitary 

 of adrenalectomized rats appears to contain less gonadotropic 

 hormone than the normal, but not in rats in which accessory 

 cortical tissue grows quickly (Del Castillo, 1934). Adrenal 



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