THE EFFECTS OF HYPOPHYSECTOMY 



White (1932) found that spermatozoa survived (judged by 

 motihty) about three weeks after either hypophysectomy or 

 after hypophysectomy and castration. Reiss, Druckrey, and 

 Hochwald (1933) investigated the metabohsm of isolated 

 testicular tissue of rats weighing about 100 g. when hypophy- 

 sectomized. Even 4 days after operation the oxygen con- 

 sumption of the isolated testis was reduced. After about 15 



Fig. 15. — The testis after hypophysectomy. Left: A testis of the hypophysecto- 

 mized rat of Figure 1 1 ; weight of both testes, 0.577 g. (Note that the tiinicae were 

 accidentally injured so that some of the parenchyma testis is escaping.) Right: 

 A testis of the normal rat of Figure 1 1 ; weight of both testes, 2.694 g. 



days, the rate of anaerobic glycolysis was reduced. The rate 

 of aerobic glycolysis appeared to increase slowly. 



Sexual desire is lost more quickly and more completely 

 after hypophysectomy than after castration (Smith, 1930; 

 Wiesner and Sheard, 1933). 



Smith described in detail the changes in the female genital 

 tract of the hypophysectomized rat. Some of the changes in 

 the ovaries, uterus, and vagina are illustrated in Figures 19, 

 20, 21, 22, and 23. The principal changes in the ovary con- 

 sist of, (i) an atresia of all follicles, medium-sized or larger, 



[49] 



