THE PITUITARY BODY 



The regression of the ovarian changes following prolan 

 administration to immature mice has been studied by Zondek 

 (1933) and Kennedy (1934). Hemorrhagic follicles persisted 

 as long as 5 weeks after injection. Even after a period of 2 

 months, the ovaries of injected mice differed histologically 

 from those of normal mice, and appeared more infantile. 



Zondek and Aschheim (1928) were able to bring about an 

 enormous hypertrophy of the adult mouse ovary by repeated- 

 ly administering prolan, thus provoking an excessive forma- 

 tion of corpora lutea. Zondek (1929) also interrupted preg- 

 nancy in mice apparently because of ovarian changes follow- 

 ing the administration of prolan. Later Hirsch-Hoffmann 

 (1932) administered prolan to adult normal and pregnant 

 mice. He observed an incipient luteinzation of the walls of 

 follicles as soon as 36 hours after injection. Both Mandel- 

 stamm and Tschaikowsky (1931) and Kennedy (1934) found 

 that the repeated injection of prolan into adult mice might 

 cause a temporary sterility (also see Marshall, 1933). This 

 appeared to be due to an abnormal luteinization of ovarian 

 foUicles. The atrophic ovaries of senile mice also responded 

 to prolan in the experiments of Zondek and Aschheim (1928) 

 and Zondek (1929). Follicle-ripening and oestrus, previously 

 absent, again appeared. According to Wirz and Goecke 

 (i 93 1 ) auto-transplants of ovaries, if adequately vascularized, 

 exhibited the expected changes after the injection of prolan. 



Reiss, Druckrey, and Fischl (1932) studied the oxygen con- 

 sumption and glycolysis of isolated ovaries and uteri of mice 

 and rats which had received prolan. ^Anaerobic and especi- 

 ally aerobic glycolysis as well as oxygen consumption (maxi- 

 mum after 48 hours) were all increased in the tissues of the 

 injected animals. The changes in the metabolism of the uteri 

 appeared later and also occurred after oestrin administration 

 (also see Biingeler and Ehrhardt, 1931). 



The effect of prolan on the genital tract of the female rat. — 

 Until there is available a more complete comparison of differ- 



[186] 



