THE PITUITARY BODY 



ulation. Snyder and Wislocki (1931) found that ovulation 

 could not be produced in cats by intravenous doses caus- 

 ing ovulation in rabbits. Bourg (1930-33) has studied the 

 anatomical changes in the genital tract of cats receiving 

 repeated injections of pregnancy-urine. Ovarian changes 

 could be produced in kittens only 15 days old. In cats of all 

 ages there were observed, following the administration of 

 pregnancy-urine, cystic development of ripe or growing foUi- 

 cles, degeneration of the ova, luteinization of the membrana 

 granulosa and theca, and pseudopregnancy. Young corpora 

 lutea tended to be cystic; older corpora lutea were solid. Sim- 

 ilar ovarian changes were produced in pregnant cats without 

 apparently affecting the course of pregnancy. Gustavson and 

 van Dyke (1931) found that the uteri of cats which had re- 

 ceived injections of pregnancy-urine contracted in response 

 to sympathetic stimulation thus behaving like the pregnant 

 uterus or the uterus of the spayed cat treated with oestrin and 

 progesterone. Sympathetic stimulation caused relaxation of 

 the uterus (as in the normal non-pregnant cat) if chiefly folli- 

 cle growth occurred or if the pregnancy-urine was injected 

 into spayed cats. 



Reiss and Langendorf (1929), Mathieu (1933), and Gaebler 

 (1935) have described oestrus and anatomical changes in the 

 genital tract of the dog as a result of the administration of 

 prolan. 



The efect of prolan on the genital tract of female primates. — 

 Novak and Kun (1931), Engle (1932-34), Marshall (1933), 

 and Hartman (1934) have investigated the condition of 

 the genital tract of the female macaque {Macaca mulatta^ 

 Macacus rhesus) after the administration of prolan. The ob- 

 servations of Engle were the most complete and the best con- 

 trolled (see Fig. 36). Like other investigators, he found that 

 prolan did not "stimulate" the ovaries of the immature ma- 

 caque. In older monkeys it appeared to produce a lessening 

 of ovarian secretion — for the sexual skin lost its intense red 



[196] 



