THE PITUITARY BODY 



Murohara, 1929; and others). Some investigators have re- 

 ported that large doses of a relatively pure thyrotropic prepa- 

 ration or pituitary implants cause hypertrophy of the adrenal 

 cortex of guinea pigs or rats provided that the thyroid is in- 

 tact (Loeser, 1933-34; also see Eitel, Krebs, and Loeser, 1933; 

 Emery and Winter, Holmquist, McQueen-Williams, 1934); 

 Del Castillo (1934) found that adrenalectomy in the rat did 

 not affect the amount of thyrotropic hormone in the pitui- 

 tary. According to Elmer and his colleagues (1935), the in- 

 jection of adrenal cortical extract does not interfere with the 

 effect of the thyrotropic hormone on the guinea pig's thy- 

 roid. The injection of thyrotropic hormone does not affect 

 the amount of epinephrin in the adrenal gland of the guinea 

 pig (Loeser, 1934). Aron (1933) stated that the development 

 of pancreatic islet tissue of the guinea-pig embryo was has- 

 tened by the administration of either thyrotropic hormone or 

 thyroxin. The diuretic effects of anterior pituitary extract, 

 first observed by Teel, were found not to occur after thyroid- 

 ectomy (Barnes, Regan and Bueno, 1933; and Biasotti, 

 1934).^' According to a later report (Dix, Rogoff, and Barnes, 

 1935), pancreatectomy also prevents the diuresis which fol- 

 lows the injection of an anterior-lobe extract. 



Thaddea and W^aly (1934) stated that a thyrotropic ex- 

 tract facilitated erythropoiesis and leukopoiesis in the rabbit 

 (e.g., anemia due to phenylhydrazine) and in man (e.g., 

 anemia). The effects of a similar extract on the spleen and 

 leukocytes of the guinea pig were investigated by Kleine and 

 Paal (1934). 



The interrelationship of the pars neuralis and the thyroid. — 

 That there is no interrelationship, physiologically significant, 

 between the internal secretions of the posterior lobe and that 

 of the thyroid is the best interpretation of the experimental 



^' Gaebler (1935) reported that the anterior-lobe (ox) extract which he used 

 caused a storage of water later followed by a diuresis. These effects were both 

 present after thyroparathyroidectomy. 



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