THE PITUITARY AND THE THYROID 



data. Thyroidectomy and thyroid feeding were found not to 

 alter the amounts of pressor and oxytocic principles in the 

 posterior lobe (Herring, 192 1). Thyroid feeding may increase 

 the systemic effects of the pressor principle (Clark, 1929; and 

 Appel, 1932) or the action of posterior-lobe extract on the 

 isolated duodenum (Tada, 1929). In Graves's disease, pos- 

 terior-lobe extract has been said to be less effective in delay- 

 ing diuresis (Hoff and Wermer, 1927) but more effective in 

 eliciting a pressor response (Herzum and Pogany, 1927). 

 None of these data, however, supports the hypothesis that 

 there is an important functional relationship between the 

 thyroid and the pars neuralis of the pituitary. 



277] 



