METABOLISM AND THE PARS GLANDULARIS 



moval of one adrenal gland from the hypophysectomized rat 

 (Collip and others, 1933; Shumacker and Firor, 1934). 



Some of the symptoms of hypophysial deficiency may be 

 due to the insufficient secretion of adrenal cortical hormone. 

 Although Atwell (1932) considered that adrenal cortical 

 hormone "somewhat restored," histologically, the "cortical" 

 tissue of hypophysectomized tadpoles, he found (1932) no 

 change in the adrenal cortex in similar experiments in the 

 hypophysectomized rat. Evans and others (1933) concluded 

 that cortical hormone affected neither the growth nor the 

 cachexia of hypophysectomized rats; however, Atwell stated 

 that such rats were more active if they had received the 

 cortical hormone. According to Perla (1935), the lethal dose 

 of histamine in hypophysectomized rats is much lower (200- 

 400 mg.*" per kg. body-weight) than in normal rats. On the 

 other hand, after the administration of adrenal cortical hor- 

 mone, the lethal dose of histamine is raised to a level (700- 

 800 mg.^ per kg. body-weight) closely approaching that 

 which kills the normal rat. Kalk's patient (1934) with hypo- 

 physial deficiency (Simmonds' disease) was apparently bene- 

 fited by the administration of an adrenal cortical extract, 

 but not by an anterior-lobe extract. 



The adrenal cortex of the hypophysectomized rat can be 

 restored to a normal size and appearance by the administra- 

 tion of homoplastic pituitary implants (Smith, 1930); but the 

 restoration is not as easily effected as in the case of the 

 gonads. According to Evans and others (1932-33), prolan 

 (as well as the serum of pregnant mares) has no effect on the 

 adrenal cortex of the hypophysectomized rat. They found 

 that growth-promoting extracts of the anterior pituitary 

 caused cellular hypertrophy especially in the zona fasciculata, 

 as well as an increase in the amount of lipoid in the cortex. 

 They beheved that these changes were related to the bene- 



^ Apparently the author refers to the base rather than to the salt (acid phosphate) 

 which he used. 



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