THE PITUITARY BODY 



Such a dose of thyroxin protected mice against a larger dose 

 of acetonitril than did anterior-lobe extract. Symptoms re- 

 sembling those of Graves's disease have been produced in 

 man by doses of 600-1,000 guinea pig-units of thyrotropic 

 hormone (Eitel and Loeser, 1932; Schittenhelm and Eisler, 

 1932; and others). Following a latent period of several days, 

 there appeared an increased basal metabolic rate, an in- 

 creased body temperature, an increased pulse rate, a tremor 

 of the fingers, and a bruit over the thyroid. 



The metabolism of isolated thyroid tissue of the puppy 

 was increased by the addition of thyrotropic hormone as re- 

 ported by Eitel, Krebs, and Loeser (1933). Reiss, Hochwald, 

 and Druckrey (1933) injected an anterior-lobe extract into 

 rats with sarcoma (Jensen); they stated that the oxygen con- 

 sumption of isolated liver and kidney were raised as soon 

 as 2 hours after injection, but that there was no effect on 

 isolated sarcoma. These latter experiments, however, have 

 little meaning until other control observations have been 

 made. 



No correlation between the amount of thyroid-stimulating 

 hormone in the pituitary of the ox and the known seasonal 

 variations in the ox thyroid could be demonstrated (Byars 

 and others, 1932). 



Studies of the concentration of iodine or thyroxin in the 

 blood and the thyroid, as well as the distribution of iodine in 

 the blood after the administration of anterior-lobe extract, 

 have been made by Loeser (1931), Houssay and his co- 

 workers (1931, 1932), Closs, Loeb, and MacKay (1932), 

 Grab (1932), Schittenhelm and Eisler (1932), Foster, Gut- 

 man, and Gutman (1933), and Holmquist (1934) in the 

 guinea pig, sheep, dog, and man. The total amount of iodine 

 in the thyroid is not much changed by hypophysectomy; the 

 operation, however, reduces the concentration of iodine in 

 the blood (Loeser). Thyroidectomy, of course, prevents the 

 increase in blood iodine following the injection of anterior- 



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