METABOLISM AND THE PARS GLANDULARIS 



dog: Houssay and others) or after thyroidectomy or gonad- 

 ectomy or splanchnotomy (dog: Houssay and others). Ac- 

 cording to Anselmino, Hoffmann, and Herold, the important 

 changes in the cortex consist of hypertrophy and hyperplasia 

 of the cells of the zona fasciculata and the zona glomerulosa; 

 they stated that the gonad-stimulating hormone(s) affects 

 the zona reticularis. They concluded that they had sepa- 

 rated a "hormone" different from all known "hormones" of 

 the pars glandularis. Collip, Anderson, and Thomson be- 

 lieved that the hormone stimulating the adrenal cortex dif- 

 fered from the thyrotropic hormone and from that promoting 

 growth. 



Anselmino, Herold, and Hoffmann (1934) also concluded 

 that they had secured an extract of the pars glandularis 

 which, only 1 hours after injection, caused changes in the 

 microscopic appearance of the cells of the medulla of the 

 adrenal of male mice and rats (loss of chromaffin property, 

 vacuolization, and alteration in the cells' shape). To account 

 for the changes they postulated an "adrenotropic" hormone 

 different from a cortex-stimulating or "corticotropic" hor- 

 mone. Houssay and his co-workers (1933) found that an 

 anterior-lobe extract, causing adrenal hypertrophy in the 

 dog, at first brought about a reduction, both relative and 

 absolute, in the amount of epinephrin present. Later, the 

 concentration but not the total amount of epinephrin was 

 reduced in comparison with that of normal dogs. 



The anatomy of the pituitary body in adrenalectomized 

 rats has been studied by Lehmann (1929) and Shumacker and 

 Firor (1934). In the pars glandularis the important change 

 is described as a reduction in the number of basophils. In 

 black and piebald rats, pigment in the cells of the pars inter- 

 media is either absent or diminished in amount. The pars 

 neuralis is said to be edematous. 



The interrelationship of the pars glandularis, the adrenals 



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