90 



INTERNAL SECRETIONS 



both ovaries. For a discussion of the practical side of the ques- 

 tion the reader may be referred to Blair Bell's book (1920, pp. 

 180-1) where some of the chnical hterature is quoted, and to the 

 paper by Unterberger mentioned above, and to the paper by 

 Sippel (1923) from the chnic of Bumm. It would seem that, 

 wherever possible, any healthy portion of a removed ovary 

 should be engrafted. 



The question may also be discussed as to whether an ovarian 



graft can "take" when the 

 normal healthy ovaries are pre- 

 sent in the body. Bell relates 

 that in his expsriments on 

 rabbits the graft grew as well 

 when one ovary was left in situ 

 as when both were removed. 

 I made homoiotransplantations 

 on rabbits with both ovaries 

 in situ; 15 ovaries of animals 

 of the same litters were im- 

 planted into five rabbits one to 

 about three months of age. The 

 ovaries were placed on one of 

 the abdominal muscles. Two 

 months later grafts could be 

 felt in two or three animals; in 

 one of these animals the graft 

 seemed to be in a state of cystic 

 degeneration. When killed five 

 to six months after the operation 

 no remains of the grafts could 

 be found. Similar experiments 

 were recently made with success 

 by Haherlandt (1921) on adult 

 rabbits; we shall return to these experiments in Chapter V. 



There can be no doubt that a testicular or ovarian graft not 

 only can "take" in mammals and man, but that the ovary, as 

 we shall see in Chapter V., can undergo after transplantation 

 the cyclical changes of the organ in situ. 



|\' Testicular transplantations in the frog were made by Nuss- 

 haum (1909, p. 546) who went carefully into the whole question. 

 He points out that one can improve the chances of the graft 



Fig. 48. — Section through the uterus 

 of a castrated rat. Much reduced 

 muscle layers. Uterine glands 

 absent. ■ — From Marshall and 

 Jolly. 



