146 INTERNAL SECRETIONS 



by Sand (1918, pp. 117, 118, 212). Sand caused retention of the 

 testicle in rabbits and guinea pigs on one side, and removed the 

 other testicle. In these experiments the retained testicle 

 weighed two and a half times as much as a retained testicle in 

 the presence of a second normal testicle. Like Bouin and Ancel, 



^ . :^^ 



4 







Fig. 74. — Retained testicle of pig (bilateral cryptorchism). 

 X 200. No spermatogenesis; seemingly only cells of 

 Sertoli present. Normal quantity of interstitial cells. 

 - — From Ancel and Bouin. 



Sand found the interstitial tissue in a state of hypertrophy, 

 whereas the cells of Sertoli in the degenerated tubules were not 

 increased in number. But these statements of Bouin and Ancel, 

 and of Sand are., in view of our own experiments, insufficient 

 to prove that a compensatory hypertrophy of interstitial cells 

 for endocrine purposes occurs (see below). 



All the observations made on man and animals with retained 



