220 



INTERNAL"! SECRETIONS 



is revealed in the intercellular or lymphatic spaces. Athias 

 (1921) also is of the opinion that the interstitial tissue is always 

 present in the ovaries of mammals. 



There is not as yet unanimity in regard to the interstitial 

 tissue in the ovary of man. According to Seitz (1906) and 

 Wallart (1907), who examined a great number of human 

 ovaries, beginning with one in a five months old embryo and 

 ending with an ovary of a woman of 91, interstitial cells exist 

 hke those described by Limon and others for different mammals 

 as interstitial tissue. They point out that the epithelioid cells 

 with fatty inclusions are alreadv present during embryonic 



':£i f>: 



U_- 



i'», ^» .'^ ■*.■-'.•- ,'.. . ■ -■•'^■■'.■v"'A'-■ 



Fig. 100. — Section through ovary of rabbit 2^ weeks old 

 (Prot. Nr. 54). Stroma consisting of cells of con- 

 nective tissue. — Prepar. of Wagner; design of 

 Lehbert. 



life. Wallart mentions that the number of the cells increases 

 up to puberty. At the time of puberty the interstitial tissue 

 decreases; the greatest development of the interstitial tissue 

 is attained during gravidity. At the climacteric only remains 

 of the interstitial tissue are to be found. Wallart states that 

 the fatty inclusions, always present in the interstitial cells, 

 are often yellow like the fatty granules in the cells of the corpus 

 luteum; they probably contain lutein (Wallart, 1907, p. 327). 

 Winiwarter (1908) also stated that interstitial cells are to be 

 found in the human ovary. Fraenkel (1905, p. 508) and 

 Schaeffer (1911, p. 531), on the contrary, claim that not even 

 rudiments of a similar tissue are present in the ovary of the 



