ISOLATION OF SEXUAL HORMONES 



327 



of the ovary may act in a sex specific manner. The question 

 of the sex specifity of this action has been studied lately more 

 fully by Herrmann and Stein (1919, 1920, 1921) and by 

 Fellner (1921). Herrmann and Stein stated that the extract 

 of the corpus luteum inhibits the development of the generative 

 tissue in young male rats; if spermatogenesis has already 



Long. m. 

 layer 



Circ. m. 

 layer 



Mucosa 



W 



Fig 123. — Influence of extracts of corpus luteum on the uterus.— From Herr- 

 mann. 

 C. After 5 injections, x 22. 



started, degeneration of the generative tissue takes place. 

 All the male sex characters— the penis, the prostate, the 

 vesiculae seminales, etc. — were in a state of extreme under- 

 development (signs of castration). In male rabbits there was 

 on the one hand hypertrophy of the mammary glands and in 

 some cases even secretion of colostrum, and on the other signs 

 of castration in the different accessory genital glands. It is 



