490 INTERNAL SECRETIONS 



and Wilhelm on dogs published afterwards. Further Wilhelm 

 (1923) has recently published a series of six experiments 

 on rats which fully confirm, without any exception, the 

 experiments of Steinach. The improvement lasted sometimes 

 several months. 



Steinach' s observations on female rats were confirmed by 

 Kolh (1922, 1923), who experimented on a goat of 14, weighing 

 36 kgr. There were pronounced signs of senility, lack of fat, 

 flabby muscles, general debiHty to such a degree that it was 

 necessary to raise the animal on its feet to feed it; there was 

 an almost total hairlessness, a flabby udder with no milk. 

 The animal was sterile for three years. Kolb engrafted 

 ovarian fragments under the skin into the muscles and into the 

 abdominal cavity. Some weeks subsequently the animal 

 became livelier and more robust; it could get up on its legs 

 without help. In the second month after the operation the 

 udder increased in size. Two and a half months afterwards a 

 growth of hair began, and there was finally a thick coat of hair. 

 In October, about four and a half months after the operation, 

 the animal weighed 41 kgr., and it was then in a state of 

 pronounced heat for two weeks. It became pregnant, and in 

 March gave birth to a healthy kid. The animal had to be killed 

 soon after the birth of its kid on account of a gangrenous 

 mastitis. 



Steinach and Lichtenstern have employed ligature of the 

 vasa deferentia also as a method of regeneration or rejuvenation 

 in man. It is impossible here to discuss the whole question 

 from a clinical point of view. The papers of Peter Schmidt 

 (1922), Benjamin (1922) and Sand (1922 a) may be referred to. 

 Notwithstanding the differences of opinion expressed about the 

 usefulness of the operation, it seems clear that in some cases of 

 precocious senility a general improvement and a recuperation 

 of sexual potency may be induced by vasoligature. 



I have had the opportunity of seeing certain patients operated 

 on by Steinach and Peter Schmidt, and I cannot but say that 

 in some cases the effect of the operation seems to be very 

 striking and beneficial. It is probable that the method will 

 reveal its practical utility more especially in cases of precocious 

 senility {Lipschiltz, 1921). 



Various doctors have employed testicular transplantation 

 in man as a remedy against senility. The papers of Stanley 



