THE PROBLEM OF REJUVENATION 493 



It is curious to note, for instance, how the theory of the inter- 

 stitial gland put forward originally by French men of science 

 has subsequently acquired a new nationality, and is attacked 

 as the 'theory of the puberty gland' of Steinach, who, as is well 

 known, has made some of the best contributions in this field, 

 but who was not very fortunate in the choice of his term." 

 The question of the seat of hormone-production in the testicle 

 is not yet definitely solved, as we have seen especially in 

 Chapter IV.; why complicate the question of the effects of 

 transplantation or ligature in senile or precociously senile 

 individuals, or in other pathological conditions, a question which 

 is essentially practical, by confusing it with the former question 

 as to the seat of hormone-production? Such confusion is the 

 more to be avoided in view of the possibility that some of the 

 effects of hgature are not necessarily of an hormonic order at all. 

 However these problems may iinall}' be solved, there is one 

 conclusion which stands beyond the reach of controversy, and 

 that is that the testicle and the ovary are organs of internal 

 secretion, and that their hormones are sex specific. 



BIBLIOGRAPHY TO CHAPTER XII. 



[* Not seen in the original.] 



Benjamin. 1922. The Steinach operation; report of 22 cases with 



endocrine interpretation. Endocrinology, 6, p. 776. 

 *Brown-Sequard. 1889. Experiences demontrant la puissance 



dynamogenique chez rhomme d'un hquide extrait de testicules 



d'animaux. Arch, de Physiol., I, p. 651. 

 * 1889. Du role physiologique et therapeutique d'un sue extrait 



de testicules d'animaux d'apres nombre de faits observes 



chez I'homine. Ibidem, 1, p. 738. 

 * 1890. Nouveaux faits relatifs a I'injection souscoutanee chez 



Fhomme d'un liquide extrait de testicules mammiferes. 



Ibidem, 2, p. 204. 

 Gley. 1922. Senescence et endocrinologie. Bull, de VAcad. de Medec. 

 Harms. 1914. Experimentelle XJntersuchungen iXber die inner e Sekre- 



tion der Keimdriisen. Jena. 

 1922. Keimdriisen und Alterzustand. Fortschr. d. natur- 



wissensch. Forsch., 11, p. 189. 

 HosKiNS. 1921. Some current trends in endocrinology. Jl. of the 



Amer. Med. Ass., 77, p. 1459. 

 KoHN. 1921. "Verjiingung und Pubertatsdriise." Medizin. Klinik, 



17, p. 804. 

 KoLB. 1922. Uber einen Verjiingungversuch bei der Ziege. Ver- 



handl. d. schweizer. naturforsch. Oesellsch., 103, p. 311. 



