GENETIC TYPE AND THE ENDOCRINES 505 



occur, care must be taken to establish with certainty the 

 diagnosis for bulldog head and also the breed history of 

 the animal. The chromophilic proportions of high acidophilic 

 and low basophilic cells and the presence of undifferentiated 

 cystic epithelium are also variable, but are in general char- 

 acteristic of the bulldog gland. 



In contrast to the bulldog, the bassethound pituitary ad- 

 heres very closely to the normal canine pattern ; this is shown 

 by figure 1 (pi. 95). The pars nervosa is not disproportionate- 

 ly large and is completely encased by the pars distalis; the 

 pars tuberalis surrounds the infundibular stalk, which in this 

 specimen has been accidentally compressed and bent, distort- 

 ing its elongate pattern. The two F a glands (figs. 3 and 4) 

 serve as illustrations of the characteristic bassethound typed 

 infundibular stalk. In most regions the intermedia intimately 

 fuses with the nervosa, and its cells, particularly in the 

 proximal regions, invade the nervosa deeply. The section 

 illustrated in figure 1 is from the pituitary of a 7 months 

 old immature dog, 218 $ . The eosinophils are bright staining 

 and abundant, outnumbering the basophiles more than 50 to 

 1. A brother of this animal, killed at 7\ months or just about 

 at sexual maturity, gave a relative count of acidophiles to 

 basophiles of 12 to 1, showing within 19 days the sudden 

 increase of the proportion of basophiles to over four times 

 the number in the less mature animal. Another brother, 

 which had been killed at the immature age of only 5 months, 

 was rich in bright staining acidophiles and had a very low 

 proportion of basophiles, about 260 to 1. Before puberty, 

 the basophiles are not only scarce but show various incom- 

 plete stages in the process of granular formation. Some cells 

 have so few basophile granules as to seem almost empty, 

 while other cells are completely filled. The granules in young 

 cells are frequently very coarse. These pituitaries from im- 

 mature animals illustrate the early activity of the acidophiles 

 and the later occurrence of the basophilic cells and their 

 functions. 



