672 (). I>. ANDERSON 



the frequent, slight body movements, second line, the hastened 

 and markedly irregular breathing, and the vigorous, quick 

 reactions of the leg. Note that these latter reactions are 

 evoked not only by the positive Met. 120, but also by the 

 negative Met. 36, and that brief, jerky movements of the 

 leg occur frequently dining the quiet interval between the 

 two stimulations. 



The interesting fact should be noted that the behavior 

 picture shown in figure 2 (text-fig. 119) is an almost exact 

 duplicate of the behavior picture obtained in the " experi- 

 mental neurosis" in the sheep, observed by Anderson and 

 Liddell ('35). It is not claimed, however, that this dog was 

 neurotic. The symptoms here observed were transitory, as- 

 sociated directly with and limited to the period of thyroid 

 administration, while the symptoms of the "experimental 

 neurosis" were permanent. It is significant that the charac- 

 teristic signs of the nervous disturbance can be exactly re- 

 produced in the normally calm and almost phlegmatic dog 

 during thyroid administration. This fact brings to mind the 

 difficulty encountered by the clinician in making a clear-cut 

 differential diagnosis between the neurotic and the slightly 

 hyperthyroid individual . 



Dog 8819, bassethound X SaluM F,. In this animal, the 

 conditioned salivary reflex was studied and the conditioned 

 stimuli were Met. 120 (positive) and Met. 28 (negative). 

 The dog was trained for 14 months before the critical experi- 

 ments. 



After several months' training it was discovered that this 

 bitch's behavior in the kennel and in the laboratory was 

 quite different from that of the other animals employed in 

 the investigation. During the early part of the training period 

 only slight differences in normal behavior were noticed. The 

 dog often ran to avoid having the leash placed about her 

 neck to take her to the laboratory. She was also shy with 

 strange persons and with dogs placed in her pen, and fre- 

 quently allowed the companion dog to eat her food while 



