700 



O. D. ANDERSON 



Since maintenance of the dog in a chronically low state 

 of parathyroid deficiency was not practicable, the next best 

 procedure was to administer parathormone and calcium lac- 

 tate when signs of a tetanic seizure were observed. In this 

 way, periods of deficiency alternated with periods of suf- 

 ficiency, and the post-operative behavior of the dog could 

 be studied over a longer period of time. 



Parathormone (Collip), 15 units at a single injection, was 

 given subcutaneously during an attack of tetany which oc- 

 curred 3 days after the operation. After the attack had been 

 relieved, the dog was given 15 gms. of calcium lactate by 

 mouth. The same procedure and dosages were carried out at 

 intervals thereafter of 4, 7, 6, 9 and 4 days. 



TABLE 17 

 Bog 869% 



The tests of behavior during the periods of deficiency were 

 all made on the same days on which attacks of tetany oc- 

 curred. The experiment was always carried out immediately 

 after the first sign of an approaching attack and the tests 

 were usually made 4 or 5 hours before the actual seizure. 

 The behavior tests during the periods of sufficiency were all 

 made on days immediately following the seizures and therapy, 

 at which time the animal showed marked improvement. The 

 dog often appeared almost normal on these days. 



The results during the two periods are considered sepa- 

 rately in table 17. The O-R was greatly reduced as to efficiency 

 and magnitude during the parathyroid deficient period. The 



